
龙勤强,生物化学与分子生物学博士,广东省代谢病中西医结合研究中心副研究员,硕士生导师,广东药科大学高层次引进人才(2021),美国心脏协会(AHA)优秀博士后(2015),美国心血管基础科学研究会议(BCVS)青年研究学者(2014),北美华人心脏协会杰出青年学者(2015)。主持/参与国家自然科学基金、美国健康研究院(NIH)、美国心脏协会(AHA)、美国糖尿病协会(ADA)、湖北省和广东省自然科学基金等课题20余项。在国际顶级期刊《Cell Research》,《Circulation》,内分泌和代谢疾病领域权威期刊《Endocrinology》,《Human GeneTherapy》,《BBA- Molecular Basis of Disease》,《Laboratory Investigation》,《Journal of Bioenergetics and Biomembranes》和中医药领域权威期刊《Journal of Ethnopharmacology》,《Chinese Herbal Medicines》等杂志发表研究论文40余篇。兼任广东省药理学会内分泌代谢病药理专业委员会委员,广东省中西医结合学会代谢病专业委员会委员;担任《Frontiers in Endocrinology》共同编委,《Molecular and Cellular Endocrinology》,《Life Science》,《Ageing》,《Journal of Agricultural and Food Chemistry》,《Phytotherapy Research》,《Communications Biology》,《Pharmacology & Therapeutics》和《Molecular and Cellular Biochemistry》等学术杂志特邀审稿人。
【研究方向】
1. 线粒体在衰老、代谢综合征和神经退行性疾病中的作用机制。
2. 天然产物和中药药效与作用机制;基因疗法、细胞治疗和药物的研发。3. 疾病模型(包括动物模型、类器官和细胞模型)的开发与构建。
【通讯地址】
广东广州番禺大学城外环东路280号广东药科大学科技楼5F
【邮编】
510006
【电话】
020-39352577
【邮箱】
longqq@gdpu.edu.cn
【获奖情况】
1. 2014年度美国心脏协会年会优秀研究奖
2. 2014年第九届华人心脏协会杰出青年研究学者奖
3. 2014美国心血管基础科学研究会议(BCVS)青年研究学者奖
4. 首届恩科心脏协会-中国药理协会研讨会杰出青年研究学者一等奖
5. 2013年美国心脏协会大东南区博士后奖金
【科研项目】
1. 国家自然科学基金委员会,81500312,新线粒体蛋白ES1对心肌肥厚小鼠保护作用的研究,主持。
2. Greater Southeast Affiliate Postdoctoral Fellowship from AHA (美国心脏协会),13POST14180006,The protective role of a novel mitochondrial protein KNP-I in cardiac hypertrophy,主持。
3. 广东省中医药管理局,20231202,贞术调脂方对肝细胞线粒体动力学和能量代谢影响的机制研究,主持。
4. 广东省卫生健康委,A2024378,线粒体寡霉素敏感性相关蛋白对心脏功能影响及机制研究,主持。
5. 国家自然科学基金委员会,81570366,ATPIF1作为靶标治疗压力超负荷心脏肥厚和心力衰竭的效果与机制,第二。
6. 广东药科大学高层次人才启动项目,主持。
【学术论文】
1. Luo X, Li J, Cen ZF, Feng G, Hong MQ, Huang LZ*, Long QQ*. Exploring the therapeutic potential of lupeol: a review of its mechanisms, clinical applications, and advances in bioavailability enhancement[J]. Food and Chemical Toxicology, 2025, 196: 115193.
2. Liu JY, Chen Y, Cen ZF, Hong MQ, Zhang BZ, Luo X, Wang LQ, Li SS*, Xiao X*, Long QQ*. Ganoderma lucidum spore oil attenuates acute liver injury by modulating lipid metabolism and gut microbiota[J]. Journal of Pharmaceutical and Biomedical Analysis, 2025, 256: 116674.
3. Huang XH, Qin BT, Fang ZF, Che LQ, Lin Y, Xu SY, Zhuo Y, Hua L, Jiang XM, Sun MM, Wang HR, Wu D, Long QQ*, Feng B*. Reduction of Atp5b protects mice from diet-induced obesity[J]. Genes & Diseases, 2025, 12(2): 101276.
4. Zhang YH, Jiao XY, Liu JY, Feng G, Luo X, Zhang MY, Zhang BZ, Huang LZ, Long QQ*. A new direction in chinese herbal medicine ameliorates for type 2 diabetes mellitus: focus on the potential of mitochondrial respiratory chain complexes[J]. J. Ethnopharmacol., 2024, 321: 117484.
5. Zhang MY, Luo X, Zhang BZ, Luo DS*, Huang LZ*, Long QQ*. Unveiling OSCP as the potential therapeutic target for mitochondrial dysfunction-related diseases[J]. Life Sci., 2024, 336: 122293.
6. Liu JY, Zhang BZ, Wang LQ, Li SS*, Long QQ*, Xiao X*. Bioactive components, pharmacological properties and underlying mechanism of Ganoderma lucidum spore oil: a review[J]. Chinese Herbal Medicines, 2024, 16(3): 375-391.
7. Chen KX, Ling JL, Zhou XY, Zhang MY, Long QQ*, Huang LZ*. Deciphering the anti-senescence immune paradigm: Kidney yin-yang equilibrium in traditional Chinese medicine[J]. Journal of Holistic Integrative Pharmacy, 2024, 5(2): 77-89.
8. Zhang KL, Bao R, Huang FY, Yang K, Ding YS, Lauterboeck L, Yoshida M, Long QQ*, Yang QL*. ATP synthase inhibitory factor subunit 1 regulates islet β-cell function via repression of mitochondrial homeostasis[J]. Lab Invest, 2022, 102(1): 69-79.
9. Zhou Z, Zhang KL, Liu ZH, Gao X, Huang K, Chen C, Wang DW, Yang QL*, Long QQ*. ATPAF1 deficiency impairs ATP synthase assembly and mitochondrial respiration[J]. Mitochondrion, 2021, 60: 129-141.
10. Zhou Z, Liu ZH, Gao X, Long QQ*. Mitochondrial respiration in C57BL/6 substrains varies in response to myocardial infarction[J]. J Bioenerg Biomembr, 2021, 53(2): 119-127.
11. Liu ZH, Gao X, Zhou Z, Kang SW, Yang Y, Liu H, Zhang CQ, Wen Z, Rao XQ, Wang DW, White D, Yang QL*, Long QQ*. San1 deficiency leads to cardiomyopathy due to excessive R-loop-associated DNA damage and cardiomyocyte hypoplasia[J]. Biochimica et Biophysica Acta- Molecular Basis of Disease, 2021, 1867(11): 166237.
12. Guo YY, Zhang KL, Gao X, Zhou Z, Liu ZH, Yang K, Huang K, Yang QL*, Long QQ*. Sustained oligomycin sensitivity conferring protein expression in cardiomyocytes protects against cardiac hypertrophy induced by pressure overload via improving mitochondrial function[J]. Hum Gene Ther, 2020, 31(21-22): 1178-1189.
13. Long QQ, Lei T, Feng B, Yin CJ, Jin D, Wu YL, Zhu XY, Chen XD, Gan L, Yang ZQ. Peroxisome proliferator-activated receptor-gamma increases adiponectin secretion via transcriptional repression of endoplasmic reticulum chaperone protein ERp44[J]. Endocrinology, 2010, United States, 151(7): 3195-3203.
14. He L, Kim T, Long QQ, Liu J, Wang PY, Zhou YQ, Ding YS, Prasain J, Wood PA, Yang QL. Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity[J]. Circulation, 2012, 126(14): 1705-1716.
15. Magadum A, Ding YS, He L, Kim T, Vasudevarao MD, Long QQ, Yang K, Wickramasinghe N, Renikunta HV, Dubois N, Weidinger G, Yang QL, Engel FB. Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair[J]. Cell Res., 2017, 27(8): 1002-1019.