
王玮璇,女,1993年生,广东药科大学副研究员,硕士生导师。2018年博士毕业于清华大学,获生物学博士学位。获中国科协青年托举人才。担任中国中西医结合学会科研院所工作委员会青年委员,广东省中西医结合学会代谢病专业委员会委员,广东省中西医结合学会实验医学专业委员会委员。
共主持科研项目5项(其中国家级项目1项,省级项目2项)。以第一作者或通讯作者身份发表论文14篇,其中SCI论文13篇(包括中科院1区2篇,2区6篇)。
【研究方向】
糖脂代谢病的病理机制及有效方药防控研究。
【通讯地址】
广东广州番禺大学城外环东路280号广东药科大学科技楼4楼
【邮编】
510006
【邮箱】
wangweixuan@gdpu.edu.cn
【科研项目】
1. 国家自然科学基金-青年科学基金项目,2024.01-2026.12,主持。
2. 广东省基础与应用基础研究基金自然科学基金-面上项目,2021.01-2023.12,主持。
3. 广东省基础与应用基础研究基金项目-青年基金项目,2020.01-2022.12,主持。
4. 广东省普通高校青年创新人才类项目,2019.09-2021.06,主持。
5. 广东省医学科学技术研究基金,2019.07-2021.06,主持。
【学术论文】
1. Wang WX, Liang MJ, Wang LX, Bei WJ, Guo J. 15-Hydroxyprostaglandin dehydrogenase inhibitor SW033291 ameliorates hepatic abnormal lipid metabolism, ER stress, and inflammation through PGE2/EP4 in T2DM mice[J]. Bioorganic Chemistry, 2023, 137: 106646.(中科院大类2区TOP期刊)
2. Wang WX, Zhan WJ, Liang MJ, Huang YF, Liu Y, Wang LX, Bei WJ, Guo J. Ginsenoside Rb1 ameliorates the abnormal hepatic glucose metabolism by activating STAT3 in T2DM mice[J]. Journal of functional foods, 2023, 104: 105534.(中科院大类2区)
3. Wang WX, Liang MJ, Wang LX, Bei WJ, Rong XL, Xu JQ, Guo J. Role of prostaglandin E2 in macrophage polarization: insights into atherosclerosis[J]. Biochemical Pharmacology, 2023, 207: 115357.(中科院大类2区)
4. Wang WX, Yang CM, Wang TX, Deng HT. Complex roles of nicotinamide N-methyltransferase in cancer progression[J]. Cell Death & Disease, 2022, 13(3): 267.(中科院大类1区TOP期刊)
5. Wang WX, Zhong X, Guo J. Role of 2‑series prostaglandins in the pathogenesis of type 2 diabetes mellitus and non‑alcoholic fatty liver disease (Review)[J]. International Journal of Molecular Medicine, 2021, 47(6): 114.(中科院大类3区)
6. Liang MJ, Wang LX, Wang WX. The 15-hydroxyprostaglandin dehydrogenase inhibitor SW033291 ameliorates abnormal hepatic glucose metabolism through PGE2-EP4 receptor-AKT signaling in a type 2 diabetes mellitus mouse model[J]. Cellular Signalling, 2023, 108: 110707. (中科院大类2区)
7. Yin JY, Huang YF, Wang K, Zhong Q, Liu Y, Ji ZR, Liao YW, Ma ZY, Bei WJ, Wang WX. Ginseng extract improves pancreatic islet injury and promotes β-cell regeneration in T2DM mice[J]. Frontiers in Pharmacology, 2024, 15: 1407200.(中科院大类2区)
8. Huang YF, Liang MJ, Liao YW, Ji ZR, Lin WF, Pu XJ, Wang LX, Wang WX. Investigating the mechanisms of 15-PGDH inhibitor SW033291 in improving type 2 diabetes mellitus: insights from metabolomics and transcriptomics[J]. Metabolites, 2024, 14(9): 509.(中科院大类3区)
9. Liang MJ, Zhan WJ, Wang LX, Bei WJ, Wang WX. Ginsenoside Rb1 promotes hepatic glycogen synthesis to ameliorate T2DM through 15-PGDH/PGE2/EP4 signaling pathway[J]. Diabetes, Metabolic Syndrome and Obesity: targets and therapy, 2023, 16: 3223-3234. (中科院大类3区)
10. Wang WX, Yang CM, Deng HT. Overexpression of 15-hydroxyprostaglandin dehydrogenase inhibits A549 lung adenocarcinoma cell growth via inducing cell cycle arrest and inhibiting epithelial-mesenchymal transition[J]. Cancer Management and Research, 2021, 13: 8887-8900.(中科院大类4区)
11. Liu Y, Zhan WJ, Wang LX, Wang WX. NAD pathways in diabetic coronary heart disease: unveiling the key players[J]. Current Medicinal Chemistry, 2024. (中科院大类4区)
12. Wang WX, Hu YD, Wang XF, Wang QT, Deng HT. ROS-mediated 15-hydroxyprostaglandin dehydrogenase degradation via cysteine oxidation promotes NAD+-mediated epithelial-mesenchymal transition[J]. Cell Chemical Biology, 2018, 25(3): 255-261. e4. (中科院大类1区TOP期刊)
13. Wang WX, Hu YD, Yang CM, Zhu SB, Wang XF, Zhang ZY, Deng HT. Decreased NAD activates STAT3 and integrin pathways to drive epithelial-mesenchymal transition[J]. Molecular & Cellular Proteomics, 2018, 17(10): 2005-2017.(中科院大类2区)
14. 詹雯静, 梁铭杰, 刘媛, 黄远凤, 王玮璇. STAT3抑制剂及烟酰胺联合用药对肝癌HepG2细胞增殖的抑制作用及机制研究[J]. 天津医药, 2022, 50(07): 686-692.(北大核心)